ampicillin + cloxacillin capsule 500mg,10x10capsules
Indications
It is indicated for the treatment of the following infections including mixed Gram-positive (except methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative staphylococcus (MRCoNS)) and Gram-negative infections.
Dosage and Administration
Usage: oral. Administer the dose ½ to 1 hr. before meals.
Dosage: Adult: 500 mg to 1.0 gm every 6 hrs. or more often depending on the severity of infection or as directed by the Physician.
Children: 1 month -2 yrs.: ¼ the adult dose. 2 yrs-10 yrs. ½ the adult dose.
Precautions & Warning:
1.Hypersensitivity reactions
Before initiating therapy with Ampicillin and Cloxacillin,careful inquiry should be made concerning previous hypersensitivity reactions to beta-lactams. Although anaphylaxis is more frequent following parenteral therapy, it has occurred in patients on oral penicillins. These reactions are more likely to occur in individuals with a history of beta-lactam hypersensitivity. If an allergic reaction occurs, Ampicillin and Cloxacillin should be discontinued and the appropriate alternative therapy instituted. All adverse reactions should be treated symptomatically.
2.Pseudomembranous colitis has been reported with the use of antibiotics and may range in severity from mild to life-threatening. If prolonged or significant diarrhoea occurs or the patient experiences abdominal cramps, treatment should be discontinued immediately and the patientinvestigated further.
3.Dosage should be adjusted in patients with renal impairment.
Cloxacillin can displace bilirubin from protein-binding sites. Normal caution should therefore be exercised in the treatment of jaundiced neonates.
Contraindications:
Ampicillin and Cloxacillin capsule should not be given to patients with a history of hypersensitivity to beta-lactam antibiotics (e.g., penicillins, cephalosporins) or excipients. Ampicillin and Cloxacillin is contraindicated for ocular administration.
Adverse Reactions:
1.Blood and lymphatic system disorders
2.Immune system disorders
3.Nervous system disorders
4.Gastrointestinal disorders Common: Diarrhoea and nausea
5.Hepatobiliary disorders
6.Skin and subcutaneous tissue disorders
Common: Skin rash, urticaria,and pruritus.The incidence of skin rash, pruritus, and urticaria is higher in patients suffering from infectious mononucleosis and acute or chronic leukaemia of lymphoid origin.
7.Renal and urinary disorders.
Drug interactions:
Probenecid decreases the renal tubular excretion of Ampicillin and Cloxacillin. Concurrent use with Ampicillin and Cloxacillin may result in increased and prolonged blood levels of Ampicillin and Cloxacillin. In common with other antibiotics, Ampicillin and Cloxacillin may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives. Bacteriostatic drugs may interfere with the bactericidal action of Ampicillin and Cloxacillin. Concurrent administration of allopurinol during treatment with Ampicillin and Cloxacillin can increase the likelihood of allergic skin reactions.
Storage instructions:
Store below 30°C in cool and dry place.