penicillin vk tablets 250mg,10×10tablets
Indications
1. Streptococcal infections:Pharyngitis;Scarlet fever;Skin and soft tissue infections (e.g. erysipelas);
2. Pneumococcal infections:Pneumonia;Otitis media;Vincent's gingivitis and pharyngitis
3. Prophylaxis of rheumatic fever and/or chorea Prophylaxis of pneumococcal infection (e.g. in asplenia and in patients with sickle cell disease).
Dosage and Administration
Usage: Oral
Dosage:
1.Adults: 250-500 mg every six hours.
2.Children 1-5 years: 125 mg every six hours
3.6-12 years: 250 mg every six hours
4.Elderly: The dosage is as for adults. The dosage should be reduced if renal function is markedly impaired.
Precautions & Warning:
1. Penicillin VK Tablets should be given with caution to patients with a history of allergy, especially to other drugs. Penicillin VK Tablets should also be given cautiously to cephalosporin-sensitive patients, as there is some evidence of partial cross-allergenicity between the cephalosporins and Penicillin VK Tablets.
2. Particular caution should be exercised in prescribing Penicillin VK Tablets to patients with an allergic diathesis or with bronchial asthma.
3. Oral Penicillin VK Tablets are not indicated in patients with severe illness or with a gastrointestinal disease that causes persistent nausea, vomiting, gastric dilation, cardiospasm, intestinal hyper motility or diarrhoea, because absorption may be reduced.
4. Streptococcal infections should be treated for a minimum of 10 days and post therapy cultures should be performed to confirm the eradication of the organisms.
5. Caution should be used when treating patients with a history of antibiotic associated colitis.
Contraindications:
1.Penicillin VK Tablets is contraindicated in patients with known penicillin hypersensitivity.
2. Attention should be paid to possible cross-sensitivity with other beta-lactam antibiotics e.g. cephalosporins. Severe acute infections should not be treated with Penicillin VK Tablets.
Adverse Reactions:
1. Hypersensitivity
Potential allergic reactions include urticaria, angioneurotic oedema, erythema multiforme, exfoliative dermatitis, fever, joint pain, serum sickness-like reactions, haemolytic anaemia, interstitial nephritis or anaphylactic shock (which could be fatal) with collapse and anaphylactoid reactions (asthma, purpura, gastrointestinal symptoms).
2. Gastro-intestinal tract
Nausea, diarrhoea, vomiting, stomatitis and glossitis are sometimes seen.
Sustained severe diarrhoea should prompt suspicion of pseudomembranous colitis.
3. Blood
Eosinophilia, haemolytic anaemia, leukopenia, thrombocytopenia and agranulocytosis are extremely rare. Other possible effects on the blood composition include: neutropenia, haemolytic anaemia and coagulation disorders.
4. Central nervous system
Central nervous system toxicity, including convulsions, has been reported, especially following high doses or in severe renal impairment.
Storage instructions:
Do not store above 25° C.