glucose injection 5%,250ml
Indications
1.Glucose 5% is indicated for the treatment of carbohydrate and fluid depletion.
2.Glucose 5% is also used as a vehicle and diluent for compatible medicinal products for parenteral administration.
Dosage and Administration
Dosage:
The recommended dosage for treatment of carbohydrate and fluid depletion is:
1.For adults: 500 ml to 3 litres/24h
2.For babies and children :
Weight | Dosage |
0-10 kg body weight | 100 ml/kg/24h |
10-20 kg body weight | 1000 ml + 50 ml /kg over 10 kg / 24h |
> 20 kg body weight | 1500 ml + 20 ml / kg over 20 kg / 24h. |
Usage: Intravenous Infusion
Contraindications:
1.The solution is contraindicated in case of uncompensated diabetes, other known glucose intolerances (such as metabolic stress situations), hyperosmolar coma, hyperglycaemia, hyperlactataemia.
2.Hypersensitivity to the active substance.
Precautions & Warning:
1.Dilution and other effects on serum electrolytes:Hyperosmolality, osmotic diuresis and dehydration; Hypoosmolality; Electrolyte disturbances.
2.Hyperglycaemia
3.Effects on Insulin Secretion
4.Hypersensitivity Reactions
5.Refeeding syndrome
6.Paediatric glycaemia-related issues
7.Paediatric hyponatraemia-related issues
8.Blood
9.Risk of Air Embolism
Adverse reaction
1.Immune system disorders:Anaphylactic reaction; Hypersensitivity*
2.Metabolism and nutrition disorders: Hypokalaemia;Hypomagnesaemia; Hypophosphatemia; Hyperglycaemia; Dehydration; Hypervolaemia; Hospital acquired hyponatraemia
3.Nervous system disorders: Hyponatraemic encephalopathy
4.Skin and subcutaneous tissue disorders: Rash
5.Vascular disorders: Venous thrombosis ; Phlebitis
6.Renal and urinary disorders: Polyuria;
7.General disorders and administration site conditions: Chills; Pyrexia; Infusion site infection; Infusion site irritation for example erythema; Extravasation; Local reaction; Pain localised.
Drug interactions:
1.Both the glycaemic effects of Glucose 5% and its effects on water and electrolyte balance should be taken into account when using Glucose 5% in patients treated with other substances that affect glycaemic control, or fluid and/or electrolyte balance.
2.Concomitant administration of catecholamines and steroids decreases the glucose up-take
3.Drugs leading to an increased vasopressin effect.
4.The below listed drugs increase the vasopressin effect, leading to reduced renal electrolyte free water excretion and increase the risk of hospital acquired hyponatraemia following inappropriately balanced treatment with i.v. fluids.
5.Drugs stimulating vasopressin release, e.g.: Chlorpropamide, clofibrate, carbamazepine, vincristine, selective serotonin reuptake inhibitors, 3.4-methylenedioxy-N- methamphetamine, ifosfamide, antipsychotics, narcotics
6.Drugs potentiating vasopressin action, e.g.: Chlorpropamide, NSAIDs, cyclophosphamide
7.Vasopressin analogues, e.g.: Desmopressin, oxytocin, terlipressin
Storage instructions:
50 and 100 ml bags: Do not store above 30° C.