norfloxacin capsule 100mg 12x25capsules
Indications
1.Urinary tract infections
2.Sexually transmitted diseases
3.Prostatitis
Dosage and Administration
Usage: Oral
Dosage:
Infection | Description | Unit Dose | Frequency | Duration | Daily Dose |
Urinary tract infections Infection | Uncomplicated Urinary tract infections's (cystitis) due to E. coli, K.pneumoniae, or P. mirabilis | 400 mg | q12h | 3 days | 800 mg |
Uncomplicated Urinary tract infections's due to other indicated organisms | 400 mg | q12h | 7-10 days | 800 mg | |
Complicated Urinary tract infections's | 400 mg | q12h | 10-21 days | 800 mg | |
Sexually Transmitted Diseases | Uncomplicated Gonorrhea | 800 mg | Single Dose | 1 day | 800 mg |
Prostatitis | Acute or Chronic | 400 mg | q12h | 28 days | 800 mg |
PrecaUrinary tract infectionsons & Warning:
1.Tendinopathy and Tendon Rupture
2.Exacerbation of Myasthenia Gravis
3.Central Nervous System Effects/Disorders
4.Hypersensitivity Reactions
5.Peripheral Neuropathy
6.Syphilis Treatment
Contraindications:
Norfloxacin is contraindicated in persons with a history of hypersensitivity, tendinitis, or tendon rupture associated with the use of Norfloxacin or any member of the quinolone group of antimicrobial agents.
Adverse Reactions:
1.Gastrointestinal experiences including: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers (gastric/duodenal) and vomiting.
2.Abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritus, rashes and tinnitus.
3.Additional adverse experiences reported occasionally include: Body as a Whole:fever, infection, sepsis , Cardiovascular System, Digestive System, Hemic and Lymphatic System, Metabolic and Nutritional, Nervous System, Respiratory System, Skin and Appendages, Special Senses, Urogenital System.
Drug interactions:
1.Quinolones, including Norfloxacin, have been shown in vitro to inhibit CYP1A2. Concomitant use with drugs metabolized by CYP1A2 (e.g., Caffeine, Clozapine, Ropinirole, Tacrine, Theophylline, Tizanidine) may result in increased substrate drug concentrations when given in usual doses.
2.Elevated serum levels of Cyclosporine have been reported with concomitant use of cyclosporine with Norfloxacin
3.Quinolones, including Norfloxacin, may enhance the effects of oral anticoagulants, including Warfarin or its derivatives or similar agents.
4.The concomitant administration of Quinolones including Norfloxacin with Glyburide (a sulfonylurea agent) has, on rare occasions, resulted in severe hypoglycemia.
5.Diminished urinary excretion of Norfloxacin has been reported during the concomitant administration of probenecid and Norfloxacin
Storage instructions:
Store at temperature not exceeding 30°C in a dry place. Protect from light.