IndicationsUsed for hemorrhagic disorders caused by vitamin K deficiency, such as neonatal hemorrhage, vitamin K deficiency due to malabsorption, and hypoprothrombinemia.Dosage and AdministrationUsage
Indications
Used for hemorrhagic disorders caused by vitamin K deficiency, such as neonatal hemorrhage, vitamin K deficiency due to malabsorption, and hypoprothrombinemia.
Dosage and Administration
Usage:
1. Hemostasis: Intramuscular injection of 2-4 mg once, 4-8 mg per day; to prevent neonatal bleeding, intramuscular injection can be given to pregnant women one week before delivery, 2-4 mg per day.
2. Antispasmodic and analgesic: Intramuscular injection, 8-16 mg each time.
Precautions & Warning:
1. Vitamin K carries a risk of allergic reactions.
2. When patients experience severe bleeding due to vitamin K-dependent factor deficiency, short-term administration is often insufficient for immediate effect. In such cases, prothrombin complex concentrate, plasma, or fresh blood may be administered intravenously first.
3. When used to correct hypoprothrombinemia caused by oral anticoagulants, the lowest effective dose should be tried first and adjusted based on prothrombin time measurements; excessive vitamin K can make subsequent continuous anticoagulant therapy difficult.
4. This product is ineffective for bleeding in patients with cirrhosis or advanced liver disease, and for bleeding caused by heparin.
Contraindications:
Adverse Reactions:
1. Localized redness and pain may be observed.
2. Large doses can cause hemolytic anemia, hyperbilirubinemia, and jaundice in newborns and premature infants. It can also induce acute hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency.
3. High doses may cause liver damage. Vitamin K1 may be used as an alternative in patients with impaired liver function.
Drug interactions:
1. Oral anticoagulants such as coumarin derivatives can interfere with vitamin K metabolism; when these drugs are used together, their effects counteract each other.
2. Large doses of salicylates, sulfonamides, quinine, and quinidine can also affect the effects of vitamin K.
Storage instructions:
Store in a cool, dry place, protected from light, in a tightly sealed container.